Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism

Abstract Drug-resistant bacteria pose an urgent global health threat, necessitating the development of antibacterial compounds with novel modes of action. Protein biosynthesis accounts for up to half of the energy expenditure of bacterial cells, and consequently inhibiting the efficiency or fidelity...

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מידע ביבליוגרפי

Principais autores:	Laleh Khodaparast, Ladan Khodaparast, Ramon Duran-Romaña, Guiqin Wu, Bert Houben, Wouter Duverger, Matthias De Vleeschouwer, Katerina Konstantoulea, Fleur Nysen, Thomas Schalck, Daniel J. Curwen, Lisandra L. Martin, Sebastien Carpentier, Bernard Scorneaux, Jan Michiels, Joost Schymkowitz, Frederic Rousseau
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Portfolio 2025-02-01
סדרה:	Nature Communications
גישה מקוונת:	https://doi.org/10.1038/s41467-025-56873-z
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