Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens

Critical residue variations in two of the most clinically prevalent DHFR isoforms are identified as a common structural element in trimethoprim-resistant DHFR which impose changes on enzyme catalysis and ligand-cofactor cooperativity.

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Jolanta Krucinska, Michael N. Lombardo, Heidi Erlandsen, Alexavier Estrada, Debjani Si, Kishore Viswanathan, Dennis L. Wright
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2022-05-01
Rangatū:	Communications Biology
Urunga tuihono:	https://doi.org/10.1038/s42003-022-03384-y
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!