Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens

Critical residue variations in two of the most clinically prevalent DHFR isoforms are identified as a common structural element in trimethoprim-resistant DHFR which impose changes on enzyme catalysis and ligand-cofactor cooperativity.

Bibliografiset tiedot

Päätekijät:	Jolanta Krucinska, Michael N. Lombardo, Heidi Erlandsen, Alexavier Estrada, Debjani Si, Kishore Viswanathan, Dennis L. Wright
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2022-05-01
Sarja:	Communications Biology
Linkit:	https://doi.org/10.1038/s42003-022-03384-y
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