High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma

Abstract Background Long-chain acyl-CoA synthetase-4 (ACSL4) is involved in fatty acid metabolism, and aberrant ACSL4 expression could be either tumorigenic or tumor-suppressive in different tumor types. However, the function and clinical significance of ACSL4 in lung adenocarcinoma remain elusive....

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Detalhes bibliográficos

Principais autores:	Yixiang Zhang, Songyu Li, Fengzhou Li, Changsheng Lv, Qing-kai Yang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-05-01
coleção:	Biology Direct
Assuntos:	Long-chain acyl-CoA synthetase-4 Ferroptosis Lung adenocarcinoma High-fat diet
Acesso em linha:	https://doi.org/10.1186/s13062-021-00294-7
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