High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma

Abstract Background Long-chain acyl-CoA synthetase-4 (ACSL4) is involved in fatty acid metabolism, and aberrant ACSL4 expression could be either tumorigenic or tumor-suppressive in different tumor types. However, the function and clinical significance of ACSL4 in lung adenocarcinoma remain elusive....

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Autori principali:	Yixiang Zhang, Songyu Li, Fengzhou Li, Changsheng Lv, Qing-kai Yang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2021-05-01
Serie:	Biology Direct
Soggetti:	Long-chain acyl-CoA synthetase-4 Ferroptosis Lung adenocarcinoma High-fat diet
Accesso online:	https://doi.org/10.1186/s13062-021-00294-7
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