Enhanced tumor suppression in patient-derived temozolomide-resistant glioblastoma cells using a combination treatment of Olaparib and FK866

Abstract Glioblastoma (GBM) is a prevalent brain cancer with notorious aggressiveness in adults. Standard treatment for GBM includes surgery, radiation, and administration of Temozolomide (TMZ). However, the TMZ resistance during chemotherapy poses a significant challenge. In the recent study a pati...

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Principais autores:	Xiaowei Sha, Jiaqian Li, Yunlong Fang, Jingjie Feng, Yasong Feng, Jing Wang, Yang Si, Feng Li, Shan Cheng, Wei Ding
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-07-01
Series:	BMC Cancer
Assuntos:	GBM TMZ PARP inhibitor NAMPT Combination therapy
Acceso en liña:	https://doi.org/10.1186/s12885-025-14568-0
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