Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms.

Alkylating agents are ubiquitous in our internal and external environments, causing DNA damage that contributes to mutations and cell death that can result in aging, tissue degeneration and cancer. Repair of methylated DNA bases occurs primarily through the base excision repair (BER) pathway, a mult...

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Автори:	Carrie M Margulies, Isaac Alexander Chaim, Aprotim Mazumder, June Criscione, Leona D Samson
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Public Library of Science (PLoS) 2017-01-01
Серія:	PLoS ONE
Онлайн доступ:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184619&type=printable
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