Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury

BackgroundEdaravone dexborneol (Eda-Dex), a promising neuroprotectant composed of edaravone and (+)-borneol, has been clinically applied in stroke treatment. However, the mechanism of action of Eda-Dex remains unclear.MethodsA rat model of cerebral ischemia/reperfusion injury (CIRI) was created thro...

Полное описание

Библиографические подробности

Главные авторы:	Hui Zhang, Can Zhu, Xingyu Zhou, Laifa Wang, Ling Deng, Binsheng He, Jianming Li
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2025-04-01
Серии:	Frontiers in Pharmacology
Предметы:	edaravone dexborneol neuroprotection Nrf2/ARE pathway NF-κB/AIM2 pathway cerebral ischemia/reperfusion injury
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1581320/full
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!