Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases. Ogg1−/−Mutyh−/− mice were more active and less anxious, with i...

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Autors principals:	Monica D. Bjørge, Gunn A. Hildrestrand, Katja Scheffler, Rajikala Suganthan, Veslemøy Rolseth, Anna Kuśnierczyk, Alexander D. Rowe, Cathrine B. Vågbø, Susanne Vetlesen, Lars Eide, Geir Slupphaug, Yusaku Nakabeppu, Timothy W. Bredy, Arne Klungland, Magnar Bjørås
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2015-12-01
Col·lecció:	Cell Reports
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124715014138
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