Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus

Abstract Neonatal hypoxic-ischemic (H-I) brain injury, a leading cause of neurodevelopmental disabilities, severely affects the metabolically active and neurogenic hippocampus. To investigate its acute effects and identify drug targets for early therapeutic windows, we applied single-nucleus RNA seq...

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Detalhes bibliográficos

Principais autores:	Aleksandr Ianevski, María Cámara-Quílez, Wei Wang, Rajikala Suganthan, Gunn Hildrestrand, Jonas Viken Grini, Dagny Sanden Døskeland, Jing Ye, Magnar Bjørås
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-07-01
coleção:	Acta Neuropathologica Communications
Assuntos:	Neonatal hypoxia ischemia Single-cell RNA sequencing Hippocampal cell atlas Machine learning Neural vulnerability Gene regulatory network
Acesso em linha:	https://doi.org/10.1186/s40478-025-02062-4
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