Molecular basis for functional connectivity between the voltage sensor and the selectivity filter gate in Shaker K+ channels

In Shaker K+ channels, the S4-S5 linker couples the voltage sensor (VSD) and pore domain (PD). Another coupling mechanism is revealed using two W434F-containing channels: L361R:W434F and L366H:W434F. In L361R:W434F, W434F affects the L361R VSD seen as a shallower charge-voltage (Q-V) curve that cros...

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Détails bibliographiques

Auteurs principaux:	Carlos AZ Bassetto, João Luis Carvalho-de-Souza, Francisco Bezanilla
Format:	Artigo
Langue:	Inglês
Publié:	eLife Sciences Publications Ltd 2021-02-01
Collection:	eLife
Sujets:	v-sensing pore domain coupling S4-S5 segments W434F slow inactivation
Accès en ligne:	https://elifesciences.org/articles/63077
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