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Allosteric modulation of G protein-coupled receptor signaling

G protein-coupled receptors (GPCRs), the largest family of transmembrane proteins, regulate a wide array of physiological processes in response to extracellular signals. Although these receptors have proven to be the most successful class of drug targets, their complicated signal transduction pathwa...

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Principais autores: Siyuan Shen, Chang Zhao, Chao Wu, Suyue Sun, Ziyan Li, Wei Yan, Zhenhua Shao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-02-01
Serier:Frontiers in Endocrinology
Fag:
G protein-coupled receptors (GPCRs)
allosteric modulator
structural investigations
GPCR signaling regulation
allosteric drug discovery
Online adgang:https://www.frontiersin.org/articles/10.3389/fendo.2023.1137604/full
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