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Amyloid beta accumulations and enhanced neuronal differentiation in cerebral organoids of Dutch-type cerebral amyloid angiopathy patients

IntroductionADutch-type cerebral amyloid angiopathy (D-CAA) is a hereditary brain disorder caused by a point mutation in the amyloid precursor protein (APP) gene. The mutation is located within the amyloid beta (Aβ) domain of APP and leads to Aβ peptide accumulation in and around the cerebral vascul...

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Principais autores: Elena Daoutsali, Barry A. Pepers, Stavros Stamatakis, Linda M. van der Graaf, Gisela M. Terwindt, David A. Parfitt, Ronald A. M. Buijsen, Willeke M. C. van Roon-Mom
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-01-01
Serier:Frontiers in Aging Neuroscience
Fag:
in vitro 3D disease modeling
cerebral organoids
Dutch-type cerebral amyloid angiopathy
Aβ accumulations
astrocytes
Online adgang:https://www.frontiersin.org/articles/10.3389/fnagi.2022.1048584/full
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