Amyloid beta accumulations and enhanced neuronal differentiation in cerebral organoids of Dutch-type cerebral amyloid angiopathy patients

IntroductionADutch-type cerebral amyloid angiopathy (D-CAA) is a hereditary brain disorder caused by a point mutation in the amyloid precursor protein (APP) gene. The mutation is located within the amyloid beta (Aβ) domain of APP and leads to Aβ peptide accumulation in and around the cerebral vascul...

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Huvudupphov:	Elena Daoutsali, Barry A. Pepers, Stavros Stamatakis, Linda M. van der Graaf, Gisela M. Terwindt, David A. Parfitt, Ronald A. M. Buijsen, Willeke M. C. van Roon-Mom
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2023-01-01
Serie:	Frontiers in Aging Neuroscience
Ämnen:	in vitro 3D disease modeling cerebral organoids Dutch-type cerebral amyloid angiopathy Aβ accumulations astrocytes
Länkar:	https://www.frontiersin.org/articles/10.3389/fnagi.2022.1048584/full
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