A Few Charged Residues in Galectin‐3′s Folded and Disordered Regions Regulate Phase Separation

Abstract Proteins with intrinsically disordered regions (IDRs) often undergo phase separation to control their functions spatiotemporally. Changing the pH alters the protonation levels of charged sidechains, which in turn affects the attractive or repulsive force for phase separation. In a cell, the...

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主要な著者:	Yung‐Chen Sun, Tsung‐Lun Hsieh, Chia‐I Lin, Wan‐Yu Shao, Yu‐Hao Lin, Jie‐rong Huang
フォーマット:	Artigo
言語:	Inglês
出版事項:	Wiley 2024-11-01
シリーズ:	Advanced Science
主題:	cation‐π interaction galectin‐3 intrinsically disordered proteins liquid–liquid phase separation NMR spectroscopy prion‐like protein
オンライン･アクセス:	https://doi.org/10.1002/advs.202402570
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