Intrinsically disordered regions as drivers of protein aggregation: mechanisms, phase separation, and emerging predictive frameworks

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) lack stable tertiary structures yet perform essential roles in cellular signaling, molecular recognition, transcriptional regulation, and biomolecular assembly. Their conformational flexibility enables functional ad...

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Prif Awduron:	Rahul Kaushik, Suyong Re
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2026-07-01
Cyfres:	Frontiers in Biophysics
Pynciau:	aggregation-prone regions (APRs) intrinsically disordered proteins (IDPs) liquid–liquid phase separation (LLPS) protein aggregation protein language models (PLMs)
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/frbis.2026.1880887/full
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