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Targeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF-06747143)

Abstract The chemokine receptor CXCR4 mediates cell anchorage in the bone marrow (BM) microenvironment and is overexpressed in 25–30% of patients with acute myeloid leukemia (AML). Here we have shown that a new CXCR4 receptor antagonist IgG1 antibody (PF-06747143) binds strongly to AML cell lines an...

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Principais autores: Yanyan Zhang, Erika Saavedra, Ruoping Tang, Yin Gu, Patrick Lappin, Dusko Trajkovic, Shu-Hui Liu, Tod Smeal, Valeria Fantin, Stephane De Botton, Ollivier Legrand, Francois Delhommeau, Flavia Pernasetti, Fawzia Louache
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2017-08-01
Serier:Scientific Reports
Online adgang:https://doi.org/10.1038/s41598-017-07848-8
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