Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia

Abstract Background The CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL. Binding of the pro-survival chemokine CXCL12 with its cognate rec...

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Principais autores:	Manoj K. Kashyap, Carlos I. Amaya-Chanaga, Deepak Kumar, Brett Simmons, Nanni Huser, Yin Gu, Max Hallin, Kevin Lindquist, Rolla Yafawi, Michael Y. Choi, Ale-Ali Amine, Laura Z. Rassenti, Cathy Zhang, Shu-Hui Liu, Tod Smeal, Valeria R. Fantin, Thomas J. Kipps, Flavia Pernasetti, Januario E. Castro
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-05-01
coleção:	Journal of Hematology & Oncology
Assuntos:	Chronic lymphocytic leukemia PF-06747143 CXCR4 CXCL12 Chemokine ADCC
Acesso em linha:	http://link.springer.com/article/10.1186/s13045-017-0435-x
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