A mouse model for evaluation of efficacy and concomitant toxicity of anti-human CXCR4 therapeutics.
The development of therapeutic monoclonal antibodies through mouse immunization often originates drug candidates that are not cross-reactive to the mouse ortholog. In such cases, and particularly in oncology, drug efficacy studies are performed on human tumor xenografts or with "surrogate" anti-mous...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2018-01-01
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| Serie: | PLoS ONE |
| Accesso online: | http://europepmc.org/articles/PMC5858835?pdf=render |
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