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Single-molecule tracking of the transcription cycle by sub-second RNA detection

Transcription is an inherently stochastic, noisy, and multi-step process, in which fluctuations at every step can cause variations in RNA synthesis, and affect physiology and differentiation decisions in otherwise identical cells. However, it has been an experimental challenge to directly link the s...

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Bibliografische Detailangaben
Hauptverfasser: Zhengjian Zhang, Andrey Revyakin, Jonathan B Grimm, Luke D Lavis, Robert Tjian
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications Ltd 2014-01-01
Schriftenreihe:eLife
Schlagworte:
Online-Zugang:https://elifesciences.org/articles/01775
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