Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.

The SUMO-dependent ubiquitin ligase Slx8 plays key roles in promoting genome stability, including the processing of trapped Topoisomerase I (Top1) cleavage complexes and removal of toxic SUMO conjugates. We show that it is the latter function that constitutes Slx8's primary role in fission yeast. Th...

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Detalhes bibliográficos

Principais autores:	Roland Steinacher, Fekret Osman, Alexander Lorenz, Claire Bryer, Matthew C Whitby
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2013-01-01
Colecção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC3735562?pdf=render
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