Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?

The INSIG2 rs7566605 polymorphism was identified for obesity (BMI> or =30 kg/m(2)) in one of the first genome-wide association studies, but replications were inconsistent. We collected statistics from 34 studies (n = 74,345), including general population (GP) studies, population-based studies with s...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Iris M Heid, Cornelia Huth, Ruth J F Loos, Florian Kronenberg, Vera Adamkova, Sonia S Anand, Kristin Ardlie, Heike Biebermann, Peter Bjerregaard, Heiner Boeing, Claude Bouchard, Marina Ciullo, Jackie A Cooper, Dolores Corella, Christian Dina, James C Engert, Eva Fisher, Francesc Francès, Philippe Froguel, Johannes Hebebrand, Robert A Hegele, Anke Hinney, Margret R Hoehe, Frank B Hu, Jaroslav A Hubacek, Steve E Humphries, Steven C Hunt, Thomas Illig, Marjo-Riita Järvelin, Marika Kaakinen, Barbara Kollerits, Heiko Krude, Jitender Kumar, Leslie A Lange, Birgit Langer, Shengxu Li, Andreas Luchner, Helen N Lyon, David Meyre, Karen L Mohlke, Vincent Mooser, Almut Nebel, Thuy Trang Nguyen, Bernhard Paulweber, Louis Perusse, Lu Qi, Tuomo Rankinen, Dieter Rosskopf, Stefan Schreiber, Shantanu Sengupta, Rossella Sorice, Anita Suk, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Henry Völzke, Karani S Vimaleswaran, Nicholas J Wareham, Dawn Waterworth, Salim Yusuf, Cecilia Lindgren, Mark I McCarthy, Christoph Lange, Joel N Hirschhorn, Nan Laird, H-Erich Wichmann
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2009-10-01
Serija:	PLoS Genetics
Online dostop:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000694&type=printable
Oznake:	Označite Brez oznak, prvi označite!