HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation

Summary: Lipid accumulation in renal tubules is a major determinant of diabetic kidney disease (DKD), and activation of SREBPs plays a central role in this process. Our study aims to explore whether HSPA8, a molecular chaperone, is the master regulator of INSIG/SREBPs function in DKD. Here, we show...

Descrición completa

Detalles Bibliográficos

Principais autores:	Guangyan Yang, Chuanrui Ma, Yuanli Chen, Jiaqing Xiang, Lixing Li, Yanchun Li, Lin Kang, Zhen Liang, Shu Yang
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-03-01
Series:	Cell Reports
Assuntos:	CP: Molecular biology CP: Metabolism
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S221112472500110X
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!