An oral nanocombinatorial agent exhibits pleiotropic improvement in diabetic nephropathy via modulation of the SCAP/SREBPs pathway

Abstract The multifaceted pathogenesis and multi-cellular involvement of diabetic nephropathy (DN) stand in stark contrast to the inadequacy of conventional single-target therapeutic strategies. This disparity underscores the urgent need for novel drugs with comprehensive targeting capabilities. Her...

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Hlavní autoři:	Yu Su, Haobo Wen, Ke Hu, Cuiping Wen, Ping Wang, Lulu Zhao, Gang Zou, Wei Jiang, Yaxi Chen, Yunfei Zhao, Qiu Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-03-01
Edice:	Journal of Nanobiotechnology
Témata:	Diabetic nephropathy SCAP/SREBPs Lipid metabolic disorders Inflammation Lycorine Oral delivery
On-line přístup:	https://doi.org/10.1186/s12951-026-04301-9
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