A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer

Abstract Background Hypoxia is a hallmark of solid tumors and leads to the metabolic reprogramming of cancer cells. The role of epigenetic regulation between hypoxia and aberrant cholesterol metabolism in colorectal cancer (CRC) remains elusive. Methods Hypoxia-responsive circular RNAs (circRNAs) we...

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Ngā kaituhi matua:	Li Xiong, Hua-shan Liu, Chi Zhou, Xin Yang, Liang Huang, Hai-qing Jie, Zi-wei Zeng, Xiao-bin Zheng, Wen-xin Li, Zhan-zhen Liu, Liang Kang, Zhen-xing Liang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2023-04-01
Rangatū:	Molecular Cancer
Ngā marau:	Hypoxia Colorectal cancer Circular RNAs Cholesterol metabolism
Urunga tuihono:	https://doi.org/10.1186/s12943-023-01773-3
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!