A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer

Abstract Background Hypoxia is a hallmark of solid tumors and leads to the metabolic reprogramming of cancer cells. The role of epigenetic regulation between hypoxia and aberrant cholesterol metabolism in colorectal cancer (CRC) remains elusive. Methods Hypoxia-responsive circular RNAs (circRNAs) we...

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Bibliografiske detaljer

Principais autores:	Li Xiong, Hua-shan Liu, Chi Zhou, Xin Yang, Liang Huang, Hai-qing Jie, Zi-wei Zeng, Xiao-bin Zheng, Wen-xin Li, Zhan-zhen Liu, Liang Kang, Zhen-xing Liang
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2023-04-01
Serier:	Molecular Cancer
Fag:	Hypoxia Colorectal cancer Circular RNAs Cholesterol metabolism
Online adgang:	https://doi.org/10.1186/s12943-023-01773-3
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