Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR

Cellular mesenchymal–epithelial transition factor (c-Met), an oncogenic transmembrane receptor tyrosine kinase (RTK), plays an essential role in cell proliferation during embryo development and liver regeneration. Thioredoxin reductase (TrxR) is overexpressed and constitutively active in most tumors...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Jinhui Hu, Li Chen, Zhonghui Lu, Han Yao, Yunfei Hu, Luanqi Feng, Yanqing Pang, Jia-Qiang Wu, Zhiling Yu, Wen-Hua Chen
Format:	Artigo
Sprog:	Inglês
Udgivet:	MDPI AG 2023-01-01
Serier:	Molecules
Fag:	dual target anticancer agent c-Met inhibitor TrxR inhibitor
Online adgang:	https://www.mdpi.com/1420-3049/28/3/1304
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!