TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

ABSTRACT Thioredoxin reductase 2 (TrxR2), a radical‐trapping antioxidant, plays a critical role in cardiac defense. However, the mechanisms underlying its benefits remain unclear. In this study, we aimed to investigate whether endothelial TrxR2 prevents cardiac microvascular dysfunction in diabetic...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2026-04-01
Serie:	Advanced Science
Soggetti:	diabetic cardiomyopathy ferroptosis Lactylation modification mitophagy TrxR2
Accesso online:	https://doi.org/10.1002/advs.202521997
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!