TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

ABSTRACT Thioredoxin reductase 2 (TrxR2), a radical‐trapping antioxidant, plays a critical role in cardiac defense. However, the mechanisms underlying its benefits remain unclear. In this study, we aimed to investigate whether endothelial TrxR2 prevents cardiac microvascular dysfunction in diabetic...

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Autores principales:	Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2026-04-01
Colección:	Advanced Science
Materias:	diabetic cardiomyopathy ferroptosis Lactylation modification mitophagy TrxR2
Acceso en línea:	https://doi.org/10.1002/advs.202521997
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