Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR

Cellular mesenchymal–epithelial transition factor (c-Met), an oncogenic transmembrane receptor tyrosine kinase (RTK), plays an essential role in cell proliferation during embryo development and liver regeneration. Thioredoxin reductase (TrxR) is overexpressed and constitutively active in most tumors...

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Hlavní autoři:	Jinhui Hu, Li Chen, Zhonghui Lu, Han Yao, Yunfei Hu, Luanqi Feng, Yanqing Pang, Jia-Qiang Wu, Zhiling Yu, Wen-Hua Chen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-01-01
Edice:	Molecules
Témata:	dual target anticancer agent c-Met inhibitor TrxR inhibitor
On-line přístup:	https://www.mdpi.com/1420-3049/28/3/1304
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!