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Hexaraphane as a potential therapeutic strategy for tauopathies

Alzheimer's disease (AD) is characterized by pathological hyperphosphorylation of TAU protein, leading to neurofibrillary tangle formation, synaptic dysfunction, neuroinflammation, and neuronal loss. Hexaraphane (6-(methylsulfinyl) hexyl isothiocyanate; HXN), a bioactive compound derived from Wasabi...

Deskribapen osoa

Gorde:
Egile Nagusiak: Ángel Juan García-Yagüe, Daniel Carnicero-Senabre, Ángel Núñez, Raffaela Cipriani, Estibaliz Capetillo-Zarate, Maribel Escoll, Isao Okunishi, Ana I. Rojo, Antonio Cuadrado
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2026-05-01
Saila:Redox Biology
Gaiak:
NRF2
Hexaraphane
Tauopathies
PP2A
Neurodegeneration
Alzheimer's disease
Sarrera elektronikoa:http://www.sciencedirect.com/science/article/pii/S2213231726001059
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