PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Abstract Virus infection stimulates proto‐oncoprotein PIM1 kinase expression, but its importance and the biological functions of this process are poorly understood. Herein, PIM1 promotes IFNAR1 degradation to attenuate cellular innate immunity during human coronavirus HCoV‐OC43 infection. During vir...

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Autors principals:	Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2025-10-01
Col·lecció:	Advanced Science
Matèries:	β‐TrCP1 β‐coronavirus IFNAR1 PIM1 ubiquitination
Accés en línia:	https://doi.org/10.1002/advs.202503487
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