Inhibition and transport mechanisms of the ABC transporter hMRP5

Abstract Human multidrug resistance protein 5 (hMRP5) effluxes anticancer and antivirus drugs, driving multidrug resistance. To uncover the mechanism of hMRP5, we determine six distinct cryo-EM structures, revealing an autoinhibitory N-terminal peptide that must dissociate to permit subsequent subst...

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Bibliografiske detaljer

Principais autores:	Ying Huang, Chenyang Xue, Ruiqian Bu, Cang Wu, Jiachen Li, Jinqiu Zhang, Jinyu Chen, Zhaoying Shi, Yonglong Chen, Yong Wang, Zhongmin Liu
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2024-06-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-024-49204-1
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