Direct Evidence that Saquinavir Is Transported by Multidrug Resistance-Associated Protein (MRP1) and Canalicular Multispecific Organic Anion Transporter (MRP2)

To determine if saquinavir mesylate (saquinavir) is a substrate of human multidrug resistance-associated protein 1 (hMRP1 [ABCC1]) or hMRP2 (cMOAT, or ABCC2), MDCKII cells that overexpress either hMRP1 (MDCKII-MRP1) or hMRP2 (MDCKII-MRP2) were used to investigate saquinavir's cytotoxicity and t...

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Detalhes bibliográficos
Main Authors: Williams, Gregory C., Liu, Angela, Knipp, Gregory, Sinko, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128726/
https://ncbi.nlm.nih.gov/pubmed/12384350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.11.3456-3462.2002
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