Design, Synthesis, and Docking Study of Acyl Thiourea Derivatives as Possible Histone Deacetylase Inhibitors with a Novel Zinc Binding Group

Histone deacetylase inhibitors with zinc binding groups often exhibit drawbacks like non-selectivity or toxic effects. Thus, there are continuous efforts to modify the currently available inhibitors or to discover new derivatives to overcome these problems. One approach is to synthesize new compound...

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Hlavní autoři:	Duraid H. Al-Amily, Mohammed Hassan Mohammed
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2019-10-01
Edice:	Scientia Pharmaceutica
Témata:	histone deacetylase inhibitors acyl thiourea derivatives zinc binding group distance from zinc ion
On-line přístup:	https://www.mdpi.com/2218-0532/87/4/28
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