High-dose treatment of cathepsin B-activatable doxorubicin prodrug nanoparticles that induce tumor-specific immunogenic cell death for immunotherapy of melanoma with minimal systemic toxicity

Highly potent chemotherapy provides rapid therapeutic efficacy in melanoma, but is often limited by drug resistance, off-target toxicity, and systemic toxicity. Combination therapy with chemotherapy and immunotherapy has attracted much attention but still faces challenges such as inconsistent immune...

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Hlavní autoři:	Yoojeong Oh, Jinseong Kim, Nayeon Shim, Hyeonji Yoo, Hoyeon Lee, Yumin Jeong, Jagyeong Goo, Jeongyeon Lee, Mihee Jo, Hanhee Cho, Kwangmeyung Kim
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	KeAi Communications Co., Ltd. 2026-02-01
Edice:	Asian Journal of Pharmaceutical Sciences
Témata:	Cathepsin B-activatable prodrug Doxorubicin Melanoma Immunogenic cell death Immune checkpoint blockade Chemo-immunotherapy
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1818087626000097
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