Albumin–Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells

A family of monomodified bovine serum albumin (BSA) linked to methotrexate (MTX) through a variety of spacers was prepared. All analogues were found to be prodrugs having low MTX-inhibitory potencies toward dihydrofolate reductase in a cell-free system. The optimal conjugates regenerated their antip...

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Hlavní autoři:	Itzik Cooper, Michal Schnaider-Beeri, Mati Fridkin, Yoram Shechter
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-12-01
Edice:	Pharmaceutics
Témata:	cancer albumin disulfide glioma prodrug conjugate
On-line přístup:	https://www.mdpi.com/1999-4923/14/1/71
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