Decursin induces FLT3-ITD acute myeloid leukemia cell apoptosis by increasing the expression of the ubiquitin-conjugase UBE2L6

Abstract Mutation in the internal tandem duplication sequence of the FLT3 gene (FLT3-ITD) is linked to a poor clinical prognosis in acute myeloid leukemia (AML) patients. FLT3 inhibitors have demonstrated efficacy in improving the prognosis of AML patients with FLT3-ITD. However, the efficacy of FLT...

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Hlavní autoři:	Tianxin Zhang, Yuchen Li, Wenhao Liao, Yu Mou, Xue Zhan, Qiongying Hu, Ziyi Zhao, Daqian Xiong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-04-01
Edice:	Cell Communication and Signaling
Témata:	AML Decursin Degradation FLT3-ITD UBE2L6
On-line přístup:	https://doi.org/10.1186/s12964-025-02157-4
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