Lactate metabolism-driven lactylation: paradoxical modulation of intestinal inflammation and malignancy

Abstract Background Intestinal inflammation and malignancy represent two critical pathological states in the gut that severely impair patients’ quality of life. Understanding their molecular mechanisms holds significant therapeutic implications. Lactate plays a key role in cellular signaling and imm...

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Bibliografiska uppgifter

Huvudupphov:	Junting Liu, Yilong Liu, Hao Zhang, Zhaoshen Li, Xue Fang, Zixuan He, Yu Bai
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2026-04-01
Serie:	Journal of Translational Medicine
Ämnen:	Lactylation Lactate Inflammatory bowel disease Colorectal cancer Paradoxical modulation
Länkar:	https://doi.org/10.1186/s12967-026-08041-0
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