Endothelial Cell‐Derived Lactate Triggers Bone Mesenchymal Stem Cell Histone Lactylation to Attenuate Osteoporosis

Abstract Blood vessels play a role in osteogenesis and osteoporosis; however, the role of vascular metabolism in these processes remains unclear. The present study finds that ovariectomized mice exhibit reduced blood vessel density in the bone and reduced expression of the endothelial glycolytic reg...

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Главные авторы:	Jinhui Wu, Miao Hu, Heng Jiang, Jun Ma, Chong Xie, Zheng Zhang, Xin Zhou, Jianquan Zhao, Zhengbo Tao, Yichen Meng, Zhuyun Cai, Tengfei Song, Chenglin Zhang, Rui Gao, Chang Cai, Hongyuan Song, Yang Gao, Tao Lin, Ce Wang, Xuhui Zhou
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Wiley 2023-11-01
Серии:	Advanced Science
Предметы:	histone lactylation lactate metabolic reprogramming osteoporosis vascular metabolism
Online-ссылка:	https://doi.org/10.1002/advs.202301300
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