Loss of miR-145 promotes remyelination and functional recovery in a model of chronic central demyelination

Abstract Strategies for treating progressive multiple sclerosis (MS) remain limited. Here, we found that miR-145-5p is overabundant uniquely in chronic lesion tissues from secondary progressive MS patients. We induced both acute and chronic demyelination in miR-145 knockout mice to determine its con...

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Autors principals:	Samantha F. Kornfeld, Sarah E. Cummings, Rebecca Yaworski, Yves De Repentigny, Sabrina Gagnon, Stephanie Zandee, Samaneh Fathi, Alexandre Prat, Rashmi Kothary
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-07-01
Col·lecció:	Communications Biology
Accés en línia:	https://doi.org/10.1038/s42003-024-06513-x
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