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Profiling DNA damage response following mitotic perturbations

DNA damage arising from replication stress is well studied, but the effect of mitotic errors on genome integrity is less understood. Here the authors knock down 47 mitotic regulators and record how they impact on DNA breakage events, providing a resource for future studies on the relation between ce...

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Principais autores: Ronni S. Pedersen, Gopal Karemore, Thorkell Gudjonsson, Maj-Britt Rask, Beate Neumann, Jean-Karim Hériché, Rainer Pepperkok, Jan Ellenberg, Daniel W. Gerlich, Jiri Lukas, Claudia Lukas
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2016-12-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/ncomms13887
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