CDK9 inhibitor A09-003 overcomes TRAIL resistance via dual Mcl-1 suppression in breast cancer cells
Abstract Background Resistance to tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) is a main limitation in breast cancer therapy. Identifying effective sensitizers is crucial to overcome this hurdle. Cyclin-dependent kinase-9 (CDK-9) inhibition has recently emerged as a potential stra...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer
2026-05-01
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| coleção: | Discover Oncology |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1007/s12672-026-04958-6 |
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