Co-overexpression of BRD4 and CDK7 promotes cell proliferation and predicts poor prognosis in HCC

Aberrant expression of critical components of the trans-acting super-enhancers (SE) complex contributes to the continuous and robust transcription of oncogenes in human cancers. Small-molecule inhibitors targeting core-transcriptional components such as transcriptional bromodomain protein 4 (BRD4) a...

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Detalhes bibliográficos

Principais autores:	Xinxiu Li, Chuqian Zheng, Yue Liu, Hui Sun, Yanyan Qian, Hong Fan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-01-01
Colecção:	Heliyon
Assuntos:	BRD4 CDK7 Combined inhibition Cell proliferation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2405844024004201
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