Synthesis and biological evaluation of small molecule modulators of CDK8/Cyclin C complex with phenylaminoquinoline scaffold
Background CDK8/CycC complex has kinase activity towards the carboxyterminal domain of RNA polymerase II, and contributes to the regulation of transcription via association with the mediator complex. Different human malignancies, mainly colorectal and gastric cancers, were produced as a result of ov...
محفوظ في:
| المؤلف الرئيسي: | |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
PeerJ Inc.
2020-03-01
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| سلاسل: | PeerJ |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://peerj.com/articles/8649.pdf |
| الوسوم: |
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