Oxidative stress induces persistent telomeric DNA damage responsible for nuclear morphology change in mammalian cells.

One main function of telomeres is to maintain chromosome and genome stability. The rate of telomere shortening can be accelerated significantly by chemical and physical environmental agents. Reactive oxygen species are a source of oxidative stress and can produce modified bases (mainly 8-oxoG) and s...

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Библиографические подробности

Главные авторы:	Elisa Coluzzi, Monica Colamartino, Renata Cozzi, Stefano Leone, Carlo Meneghini, Nathan O'Callaghan, Antonella Sgura
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2014-01-01
Серии:	PLoS ONE
Online-ссылка:	http://europepmc.org/articles/PMC4212976?pdf=render
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