Oxidative stress induces persistent telomeric DNA damage responsible for nuclear morphology change in mammalian cells.

One main function of telomeres is to maintain chromosome and genome stability. The rate of telomere shortening can be accelerated significantly by chemical and physical environmental agents. Reactive oxygen species are a source of oxidative stress and can produce modified bases (mainly 8-oxoG) and s...

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Autors principals:	Elisa Coluzzi, Monica Colamartino, Renata Cozzi, Stefano Leone, Carlo Meneghini, Nathan O'Callaghan, Antonella Sgura
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2014-01-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC4212976?pdf=render
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