Oxidative stress induces persistent telomeric DNA damage responsible for nuclear morphology change in mammalian cells.

One main function of telomeres is to maintain chromosome and genome stability. The rate of telomere shortening can be accelerated significantly by chemical and physical environmental agents. Reactive oxygen species are a source of oxidative stress and can produce modified bases (mainly 8-oxoG) and s...

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מידע ביבליוגרפי

Principais autores:	Elisa Coluzzi, Monica Colamartino, Renata Cozzi, Stefano Leone, Carlo Meneghini, Nathan O'Callaghan, Antonella Sgura
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Public Library of Science (PLoS) 2014-01-01
סדרה:	PLoS ONE
גישה מקוונת:	http://europepmc.org/articles/PMC4212976?pdf=render
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