SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

Abstract Background Human innate host defense molecules, surfactant protein A1 (SP-A1), and SP-A2 differentially affect the function and proteome of the alveolar macrophage (AM). We hypothesized that SP-A genes differentially regulate the AM miRNome. Methods Humanized transgenic mice expressing SP-A...

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Principais autores:	George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani, Joanna Floros
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2017-12-01
Colecção:	Biology of Sex Differences
Assuntos:	Surfactant protein A Ozone Sex differences STAT3 IL-6
Acesso em linha:	http://link.springer.com/article/10.1186/s13293-017-0158-2
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