Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival

Surfactant protein A (SP-A) is involved in lung innate host defense and surfactant-related functions. The human SFTPA1 and SFTPA2 genes encode SP-A1 and SP-2 proteins, and each gene has been identified with numerous genetic variants. SP-A1 and SP-A2 differentially enhance bacterial phagocytosis. Sex...

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Principais autores:	Nithyananda Thorenoor, Todd M. Umstead, Xuesheng Zhang, David S. Phelps, Joanna Floros
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2018-10-01
Serija:	Frontiers in Immunology
Teme:	pulmonary surfactant protein A pneumonia infection surfactant protein A1 and A2 sex differences innate host defense
Online dostop:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02404/full
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